Neurology 1998 Sep;51(3):863-5

Cerebral manifestation of Wilson's disease successfully treated with live
transplantation

Bax RT, Hassler A, Luck W, Hefter H, Krageloh-Mann I, Neuhaus P, Emmrich P
Department of Pediatrics, Technische Universitat Munchen, Germany

Abstract
The main indication for orthotopic liver transplantation (OLTx) in Wilson's
disease (WD) is severe hepatic decompensation. Our 15-year-old patient is the
second case to date in whom OLTx was performed because of neurologic
manifestations resulting from WD. His initial condition involving recurrent
headaches, tremor, and athetoid hand movements progressively deteriorated during
therapy with D-penicillamine, zinc sulfate, and trientine until he was severely
dysarthric, unable to walk, and bedridden. After OLTx, his neurologic condition
became almost normal